Two teenagers have been seriously injured and two are on the run following a collision involving a stolen car in Epping,
Emergency services were called to the two-car collision at the intersection of Civic Drive and McDonalds Road about 2.25am on July 22.
Police have been told a white MG hatch was seen travelling at high speeds before it appears to have run a red light and collided with another vehicle.
It is believed two people from the MG have run from the scene leaving two teenagers in the car seriously injured.
The 16-year-old female and 13-year-old male have both been taken to hospital under police guard.
The 30-year male driver of the other car received minor injuries and has been taken to hospital for treatment.
A check of the car has confirmed the vehicle was stolen.
Anyone who witnessed the collision, with dashcam footage or information is urged to contact Crime Stoppers on 1800 333 000 or www.crimestoppersvic.com.au.