Police are investigating a single vehicle crash in Thomastown on Friday, February 3.
Police believe a white Mitsubishi van was travelling north on Edgars Road just after 5.30pm when the driver lost control.
The van left the road and struck a tree in the centre median strip.
The driver, a 40-year-old Mickleham woman, was taken to hospital where she remains in a stable condition.
A 40-year-old male passenger was also taken to hospital and is in a stable condition.
Anyone who witnessed the collision or has information including dashcam footage is urged to call Crime Stoppers on 1800 333 000 or log onto www.crimestoppersvic.com.au.