Police are investigating the circumstances surrounding the death of a man in Craigieburn on Saturday.
Police were called to reports of a physical altercation at a property on Thoresby Circuit about 6.45pm on January 25.
One male, who is yet to be formally identified, was located with a stab wound.
He was transported to hospital with life-threatening injuries, where he later died.
Officers arrested a 54-year-old man at the scene.
He was transported to hospital with non-life-threatening injuries under police guard.
A 54-year-old woman was also taken to hospital with non-life-threatening injuries.
Investigators believe all parties are known to each other and are not looking for any other person.
Anyone with information can contact Crime Stoppers on 1800 333 000 or www.crimestoppersvic.com.au