A stretch of Craigieburn Road will be closed for 12 days as part of duplication works.
The road will be closed between Hanson Road and Aitken Boulevard in mid-September to early October, although it will be open over the AFL Grand Final long weekend.
The closure will enable crews to relocate and install gas, water, sewerage and power along Craigieburn Road.
The state government said the works will coincide with the school holidays when there will be fewer cars on the road.
Yuroke MP Ros Spence said the works and overall Craigieburn Road upgrade would improve traffic flow, bus reliability and access to Craigieburn station.
From late October, motorists can also expect land closures on Mickleham Road as part of early works for stage one of the road’s duplication.
Safety barriers and temporary speed reduction will be in place at the intersection with Somerton Road until mid-2023.
Roadworks are also planned for Donnybrook Road during September and October.
The government said construction of a new culvert bridge on Donnybrook Road near Doreen, will begin with bridge strengthening works taking placed between Epping Road and Darebin Creek from Saturday, September 17 to Monday, October 3. Changed lane arrangement will be in place until Monday, November 7.
Train passengers can also expect disruptions, with buses replacing trains between Essendon and Craigieburn from 9pm on Wednesday, September 14 until the last service on Sunday, September 18 as part of works to upgrade signals on the Craigieburn line.
Transport Infrastructure Minister Jacinta Allan said the government was launching a spring construction blitz.
“Our over $20 billion of road and rail upgrades in the west and northwest will continue to remove level crossings and upgrade our roads and rail to build for the future and back thousands of Victorian jobs,” she said.