Broadmeadows and Dallas properties were searched by police as part an investigation into the cultivation of cannabis.
Police executed six search warrants at properties in Broadmeadows, Dallas, Glenroy, Reservoir and Albion on Friday, December 3, locating alleged hydroponic cannabis set-ups
Police said officers seized a significant quantity of cannabis plants.
A 43-year-old St Albans man was charged with possessing, trafficking and cultivating a commercial quantity of cannabis and bail offences.
He has been remanded to appear at Melbourne Magistrates Court on Monday morning
A 37-year-old St Albans man, a 23-year-old St Albans woman and a 26-year-old Sunshine man were released and are expected to be charged with cultivating commercial quantities of cannabis, to appear at a magistrates court at a later date.
Anyone with information about illicit drug activity is urged to contact Crime Stoppers on 1800 333 000 or make a confidential report at www.crimestoppersvic.com.au